Phage Therapy Current Research And Applications Pdf


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This article collection, published in Virology Journal, is intended to give new insights to the current knowledge on bacteriophage based technologies for Veterinary applications, a topic that has gained a renewed interest with the rising of bacterial resistances to the commonly used antimicrobials. They are highly genetically diverse and the most abundant biological entities on earth, being safe for humans, animals and plants.

Guidelines to Compose an Ideal Bacteriophage Cocktail

In the recent years, multidrug-resistant bacteria have become a global threat, and phage therapy may to be used as an alternative to antibiotics or, at least, as a supplementary approach to treatment of some bacterial infections. Here, we describe the results of bacteriophage application in clinical practice for the treatment of localized infections in wounds, burns, and trophic ulcers, including diabetic foot ulcers. This mini-review includes data from various studies available in English, as well as serial case reports published in Russian scientific literature with, at least, abstracts accessible in English. Since, it would be impossible to describe all historical Russian publications; we focused on publications included clear data on dosage and rout of phage administration. Since their discovery, bacteriophages have been considered to be potential antibacterial therapeutics for the treatment of various infectious diseases in humans. Initially, clinical application of bacteriophages was aimed at the treatment of acute intestinal diseases Summers, and skin infections Bruynoghe and Maisin, Later, bacteriophages were applied in surgical practice for treatment of purulent wounds and postoperative infectious complications, and this approach was used in the USSR in the thirties and forties of the twentieth century Tsulukidze, ; Kokin, ; Krestovnikova,

Phage therapy , viral phage therapy , or phagotherapy is the therapeutic use of bacteriophages to treat pathogenic bacterial infections. Phages are often compared to antibiotics. Phages tend to be more successful than antibiotics where there is a biofilm covered by a polysaccharide layer, which antibiotics typically cannot penetrate. Because phages replicate in vivo in cells of living organism , a smaller effective dose can be used. This specificity is also a disadvantage: a phage will kill a bacterium only if it matches the specific strain. Phages are currently being used therapeutically to treat bacterial infections that do not respond to conventional antibiotics, particularly in Russia [9] and Georgia. Phage therapy has many potential applications in human medicine as well as dentistry, veterinary science, and agriculture.

Emerging antibiotic resistance is one of the most important microbiological issues of the 21st century. This poses a query regarding the future use of antibiotics and availability of other promising therapeutic alternatives. The awareness about antibiotic misuse has improved insufficiently and is evident by the increased incidences of multidrug resistant infections globally. Amongst different antibacterial therapeutic approaches phage therapy has created a niche of its own due to continuous use for treatment of human infections in Eastern Europe. Synergistic compounds along with phages have also been proposed as a better alternative compared to antibiotics or phage alone for treatment of chronic cases and seriously debilitating diseases.

Taking Bacteriophage Therapy Seriously: A Moral Argument

Citation: Asija K, Teschke CM Lessons from bacteriophages part 2: A saga of scientific breakthroughs and prospects for their use in human health. PLoS Pathog 14 5 : e This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist.

This new volume is therefore a valuable resource for individuals engaged in the medical application of novel phage therapies. Hismain interests are phage therapy and immunobiology of phage. In the s he presented a hypothesis on protective action of endogenous phages which involves not only their antibacterial but also antiinflammatory and immunomodulatory action. Subsequently, he formulated a hypothesis on phage translocation from the gastrointestinal tract to other tissues where phages could mediate their effects. He was a co-editor of a book on phage therapy see above. He has published over 70 papers and five book chapters related to therapeutic phage application including new perspectives of clinical use of bacteriophages anti-inflammatory and immunomodulating phage effects. He was a co-editor of the book Phage Therapy.

Phage Therapy: A Practical Approach

The emergence of bacteria resistant to multiple antibiotics has become a serious threat to public health and is considered one of the greatest challenges for contemporary medicine. Phage therapy, the use of bacteriophages as anti-bacterial agents, may offer an alternative treatment for bacterial infections. Phages have many potential applications in human medicine as well as dentistry, veterinary science, agriculture and food protection.

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Phage Therapy: Current. Research and Applications. Edited by Jan Borysowski, Ryszard. Mie˛dzybrodzki, and Andrzej Górski. Norfolk, UK: Caister Academic.

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PDF | Bacterial antibiotic resistance is one of the foremost public health challenges of our time. Even as efforts to identify novel antibiotics and.

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