Human Cancer Cell Lines Fact And Fantasy Pdf


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21.04.2021 at 22:31
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human cancer cell lines fact and fantasy pdf

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Morcos, Solange Landreville, Sylvain L. Purpose : Development of liver metastasis remains the most common cause of mortality in uveal melanoma UM. A few cell lines cultured from primary UM tumors have been used widely to investigate the pathobiology of UM. However, the translation of basic knowledge to the clinic for the treatment of the metastatic disease has remained incremental at best.

Isogenic human disease models

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Cancer cell lines are used in many biomedical research laboratories. Why, then, are they often described as unrepresentative of the cells from which they were derived?

Verification and Unmasking of Widely Used Human Esophageal Adenocarcinoma Cell Lines

Isogenic human disease models are a family of cells that are selected or engineered to accurately model the genetics of a specific patient population, in vitro. They are provided with a genetically matched 'normal cell' to provide an isogenic system to research disease biology and novel therapeutic agents. Cancer is one such disease for which isogenic human disease models have been widely used. Human isogenic disease models have been likened to 'patients in a test-tube', since they incorporate the latest research into human genetic diseases and do so without the difficulties and limitations involved in using non-human models. Historically, cells obtained from animals, typically mice, have been used to model cancer-related pathways. However, there are obvious limitations inherent in using animals for modelling genetically determined diseases in humans.

False cell lines: The problem and a solution

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. For decades, hundreds of different human tumor type—specific cell lines have been used in experimental cancer research as models for their respective tumors.

Identification of Tamoxifen-Resistant Breast Cancer Cell Lines and Drug Response Signature

Human cancer cell lines: fact and fantasy

Breast cancer cell lines are frequently used to elucidate the molecular mechanisms of the disease. However, a large proportion of cell lines are affected by problems such as mislabeling and cross-contamination. Therefore, it is of great clinical significance to select optimal breast cancer cell lines models.

Hundreds of misleading reports are published every year containing data on human cancer cell lines that are derived from some other species, tissue or individual to that claimed. In consequence, millions of dollars provided for cancer research are being spent on the production of misleading data. This review describes how cross-contamination occurs, catalogues the use of false cell lines in leading biomedical journals, and suggests ways to resolve the problem. This is a preview of subscription content, access via your institution. Rent this article via DeepDyve. J Biol Chem — Cancer Res —

Human cancer cell lines: fact and fantasy

Oncotarget a primarily oncology-focused, peer-reviewed, open access, biweekly journal aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases.

 Какого черта тебе надо? - прорычал он хриплым голосом - с явным нью-йоркским акцентом. Сдерживая подступившую к горлу тошноту, Беккер успел заметить, что все пассажиры повернулись и смотрят на. Все как один были панки. И, наверное, у половины из них - красно-бело-синие волосы. - Sientate! - услышал он крик водителя.

Isogenic human disease models

АНБ сразу же осознало, что возникла кризисная ситуация.

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